COVID-19 infection in crucial brain regions may lead to accelerated brain aging – Neuroscience News

Neuroscience News logo for mobile.

Summary: The effects of COVID-19 infection on neurological health are becoming increasingly evident. A new study reveals that COVID-19 may predispose people to irreversible neurological conditions, accelerate brain aging and increase the risk of stroke and brain bleeds.

Source: Houston Methodist

A new study by Houston Methodist researchers reviews emerging ideas and evidence suggesting that COVID-19 infections may have both short- and long-term neurological effects.

Key findings include that COVID-19 infections can predispose people to developing irreversible neurological conditions, can increase the likelihood of stroke, and can increase the chance of developing persistent brain injuries that can lead to brain bleeding.

Led by corresponding authors Joy Mitra, Ph.D., Instructor, and Muralidhar L. Hegde, Ph.D., Professor of Neurosurgery, with the Division of DNA Repair within the Center for Neuroregeneration at the Methodist Research Institute of Houston, the research team described their findings in an article titled “SARS-CoV-2 and the Central Nervous System: Emerging Insights in Hemorrhage-Associated Neurological Consequences and Therapeutic Considerations” in the journal Aging Research Reviews.

Still a significant burden on our daily lives, a wealth of research has shown that the impacts of the disease go far beyond the actual moment of infection. Since the start of the pandemic, COVID-19 has surpassed a death toll of more than 5.49 million worldwide and more than 307 million confirmed positive cases, with the US accounting for nearly 90 million of those cases , according to the website Our World in Data. .

COVID-19 is known to invade and infect the brain, among other important organs. Although much research has been done to help us understand the development, infection and pathology of the disease, there is still much that is still unclear about the long-term effects, particularly on the brain.

Coronavirus infection can cause long-term and irreversible neurodegenerative diseases, especially in the elderly and other vulnerable populations. Several brain imaging studies of victims and survivors of COVID-19 have confirmed the formation of microhemorrhage lesions in deeper brain regions related to our cognitive and memory functions.

In this review study, researchers have critically assessed the potential chronic neuropathological outcomes in aging and comorbid populations if timely therapeutic intervention is not implemented.

Microbleeds are emerging neuropathological signatures frequently identified in individuals suffering from chronic stress, depressive disorders, diabetes, and age-related comorbidities. Building on their previous findings, the researchers discuss how microhemorrhagic lesions induced by COVID-19 may exacerbate DNA damage in affected brain cells, leading to neuronal senescence and activation of death mechanisms cellular, which ultimately affect the microstructure-vasculature of the brain.

These pathological phenomena resemble the hallmarks of neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease and are likely to worsen late-stage dementia as well as cognitive and motor deficits.

Still a significant burden on our daily lives, a wealth of research has shown that the impacts of the disease go far beyond the actual moment of infection. The image is in the public domain

The effects of COVID-19 infection on various aspects of the central nervous system are currently being studied. For example, 20-30% of patients with COVID-19 report a persistent psychological condition known as “brain fog” where people experience symptoms such as memory loss, difficulty concentrating, forgetting activities daily, difficulty in selecting the right words, take more time. longer than usual to complete a routine task, disoriented thought processes and emotional numbness.

The more serious long-term effects discussed in the Houston Methodist review article include predispositions to Alzheimer’s, Parkinson’s, and related neurodegenerative diseases, as well as cardiovascular disorders due to internal bleeding and injury induced by blood clotting in the part of the brain that regulates our respiratory system. , after symptoms of COVID-19.

In addition, cellular aging is thought to be accelerated in patients with COVID-19. A large amount of cellular stress inhibits virus-infected cells from carrying out their normal biological functions and allows them to enter “hibernation mode” or even die completely.

The study also suggests several strategies to improve some of these long-term neuropsychiatric and neurodegenerative outcomes, as well as underlines the importance of the “nanozyme” therapeutic regimen in combination with several FDA-approved drugs that may be successful in combating this . catastrophic disease

However, given the ever-evolving nature of this field, partnerships like those described in this review show that the fight against COVID-19 is far from over, the researchers say, and reinforce the message that getting vaccinated and maintaining proper hygiene are key in trying to prevent these long-term and harmful consequences.

About this news about COVID-19 and neurology research

Author: Press Office
Source: Houston Methodist
Contact: Press Office – Houston Methodist
Image: The image is in the public domain

See also

This shows a woman sleeping

Original Research: Open access
“SARS-CoV-2 and the central nervous system: emerging insights into neurological consequences and therapeutic considerations associated with hemorrhage” by Joy Mitra et al. Aging Research Reviews


Summary

SARS-CoV-2 and the central nervous system: emerging insights into neurological consequences associated with hemorrhage and therapeutic considerations

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to affect our lives by causing widespread illness and death and poses a threat due to the possibility of emerging strains . SARS-CoV-2 targets angiotensin-converting enzyme 2 (ACE2) before entering the body’s vital organs, including the brain. Studies have shown that systemic inflammation, cellular senescence, and multiorgan failure mediated by viral toxicity occur during infectious periods.

However, prognostic research suggests that both acute and long-term neurological complications, including predisposition to irreversible neurodegenerative diseases, may be a serious concern for survivors of COVID-19, especially the elderly population.

As emerging studies reveal sites of SARS-CoV-2 infection in different parts of the brain, increasing potential causes of chronic injury such as cerebral and deep brain microbleeds and the likelihood of developing stroke-like pathologies, with critical long-term consequences, especially for people with comorbid neuropathological and/or age-related conditions.

Our recent studies linking blood degradation products to genome instability, leading to cellular senescence and ferroptosis, raise the possibility of similar neurovascular events as a result of infection with SARS-CoV- 2.

In this review, we discuss the neuropathological consequences of SARS-CoV-2 infection in COVID survivors, focusing on potential hemorrhagic brain cell damage, its association with aging, and future directions for develop therapeutic strategies guided by mechanisms.

#COVID19 #infection #crucial #brain #regions #lead #accelerated #brain #aging #Neuroscience #News

Leave a Comment

Your email address will not be published.